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KMID : 0043320070300111471
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Archives of Pharmacal Research
2007 Volume.30 No. 11 p.1471 ~ p.1475
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Two New Phenolic Constituents of Humulus japonicus and their Cytotoxicity Test In Vitro
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Yu Byung-Chul
Yang Min-Cheol
Lee Kyu-Ha
Kim Ki-Hyun
Choi Sang-Un
Lee Kang-Ro
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Abstract
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Two new phenolic constituents (4 and 6), together with four known constituents, methyl ferulate (1), eugenyl-?D-glucopyranoside (2), apigenin-7-O-?D-glucopyranoside (3), and (E)-resveratrol- 3-O-?D-glucopyranoside (5) were isolated from the MeOH extract of the aerial part sof Humulus japonicus. The structures of the new compounds were determined by spectroscopic methods to be divarin-3-O-?glucopyranoside (4), and lariciresinol-9-O-?xylopyranoside (6). Compounds 1 and 3 exhibited moderate cytotoxicity against two human cancer cell lines (SK-OV-3 and HCT15) with ED50 values ranging from 8.84 to 8.79 킡
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KEYWORD
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Humulus japonicus, Lignan, Phenyl propanoid, Cytotoxicity
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